The critical radiation intensity for direct collapse black hole formation: dependence on the radiation spectral shape

It has been proposed that supermassive black holes (SMBHs) are originated from direct-collapse black holes (DCBHs) that are formed at z gtrsim 10 in the primordial gas in the case that H2 cooling is suppressed by strong external radiation. In this work, we study the critical specific intensity J^crit required for DCBH formation for various radiation spectral shapes by a series of one-zone calculations of a collapsing primordial- gas cloud. We calculate the critical specific intensity at the Lyman-Werner (LW) bands J^crit_LW,21 (in units of 10^-21 erg s^-1 Hz^-1 sr^-1 cm^-2) for realistic spectra of metal-poor galaxies. We find J^crit is not sensitive to the age or metallicity for the constant star formation galaxies with J^crit_LW,21 = 1300-1400, while J^crit decreases as galaxies become older or more metal-enriched for the instantaneous starburst galaxies. However, such dependence for the instantaneous starburst galaxies is weak for the young or extremely metal-poor galaxies: J^crit_LW,21 = 1000-1400 for the young galaxies and J^crit_LW,21 approx 1400 for the extremely metal-poor galaxies. The typical value of J^crit for the realistic spectra is higher than those expected in the literature, which affects the estimated DCBH number density n_DCBH. By extrapolating the result of Dijkstra, Ferrara and Mesinger, we obtain n_DCBH sim 10^-10 cMpc^-3 at z = 10, although there is still large uncertainty in this estimation.Comment: 11 pages, 6 figures, submitted to MNRA

Robustness of force and stress inference in an epithelial tissue

During morphogenesis, the shape of a tissue emerges from collective cellular behaviors, which are in part regulated by mechanical and biochemical interactions between cells. Quantification of force and stress is therefore necessary to analyze the mechanisms controlling tissue morphogenesis. Recently, a mechanical measurement method based on force inference from cell shapes and connectivity has been developed. It is non-invasive, and can provide space-time maps of force and stress within an epithelial tissue, up to prefactors. We previously performed a comparative study of three force-inference methods, which differ in their approach of treating indefiniteness in an inverse problem between cell shapes and forces. In the present study, to further validate and compare the three force inference methods, we tested their robustness by measuring temporal fluctuation of estimated forces. Quantitative data of cell-level dynamics in a developing tissue suggests that variation of forces and stress will remain small within a short period of time ($\sim$minutes). Here, we showed that cell-junction tensions and global stress inferred by the Bayesian force inference method varied less with time than those inferred by the method that estimates only tension. In contrast, the amplitude of temporal fluctuations of estimated cell pressures differs less between different methods. Altogether, the present study strengthens the validity and robustness of the Bayesian force-inference method.Comment: 4 pages, 4 figure

Non-Gaussian bubbles in the sky

We point out a possible generation mechanism of non-Gaussian bubbles in the sky due to bubble nucleation in the early universe. We consider a curvaton scenario for inflation and assume that the curvaton field phi, whose energy density is subdominant during inflation but which is responsible for the curvature perturbation of the universe, is coupled to another field sigma which undergoes false vacuum decay through quantum tunneling. For this model, we compute the skewness of the curvaton fluctuations due to its interaction with sigma during tunneling, that is, on the background of an instanton solution that describes false vacuum decay. We find that the resulting skewness of the curvaton can become large in the spacetime region inside the bubble. We then compute the corresponding skewness in the statistical distribution of the cosmic microwave background (CMB) temperature fluctuations. We find a non-vanishing skewness in a bubble-shaped region in the sky. It can be large enough to be detected in the near future, and if detected it will bring us invaluable information about the physics in the early universe.Comment: 6 pages, 6 figure

Multi-field open inflation model and multi-field dynamics in tunneling

We consider a multi-field open inflation model, in which one of the fields dominates quantum tunneling from a false vacuum while the other field governs slow-roll inflation within the bubble nucleated from false vacuum decay. We call the former the tunneling field and the latter the inflaton field. In the limit of a negligible interaction between the two fields, the false vacuum decay is described by a Coleman-De Luccia instanton. Here we take into account the coupling between the two fields and construct explicitly a multi-field instanton for a simple quartic potential model. We also solve the evolution of the scalar fields within the bubble. We find our model realizes open inflation successfully. This is the first concrete, viable model of open inflation realized with a simple potential. We then study the effect of the multi-field dynamics on the false vacuum decay, specifically on the tunneling rate. We find the tunneling rate increases in general in comparison with the single field case, though the increase is small unless the inflaton affects the instanton solution substantially.Comment: 13 pages, 4 figure

ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation

血球細胞分化に必要な新たな因子を同定. 京都大学プレスリリース. 2023-09-29.Delineating the dynamic transcriptional and epigenetic landscape regulating hematopoiesis. 京都大学プレスリリース. 2023-10-17.Cell differentiation is achieved by acquiring a cell type-specific transcriptional program and epigenetic landscape. While the cell type-specific patterning of enhancers has been shown to precede cell fate decisions, it remains unclear how regulators of these enhancers are induced to initiate cell specification and how they appropriately restrict cells that differentiate. Here, using embryonic stem cell–derived hematopoietic cell differentiation cultures, we show the activation of some hematopoietic enhancers during arterialization of hemogenic endothelium, a prerequisite for hematopoiesis. We further reveal that ZEB2, a factor involved in the transcriptional regulation of arterial endothelial cells, and a hematopoietic regulator MEIS1 are independently required for activating these enhancers. Concomitantly, ZEB2 or MEIS1 deficiency impaired hematopoietic cell development. These results suggest that multiple regulators expressed from an earlier developmental stage non-redundantly contribute to the establishment of hematopoietic enhancer landscape, thereby restricting cell differentiation despite the unrestricted expression of these regulators to hematopoietic cells